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Harvard Men's Health Watch. Many drugs have been implicated as occasional causes of gynecomastia.

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MicroRNA gene expression deregulation in human breast cancer. An overactive thyroid gland can also produce it.

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Old age is another occasional cause, probably because testosterone levels tend to decline over the years. The breast enlargement is usually mild and painless, but about a third of men complain of tenderness. Ultimately, it is hoped that such investigations may lead to genetically oriented treatments for male breast cancer.